脱乙酰茴香霉素是一种有效的植物生长调节剂，是茴香霉素的无活性衍生物。
货号:ajcx28556
CAS:27958-06-1
分子式:C12H17NO3
分子量：223.3
溶解度:Methanol: soluble
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Deacetylanisomycin is a derivative of the protein and DNA synthesis inhibitor anisomycin with antimalarial and anticancer activity.^1,2It inhibits the growth of theP. falciparumstrains K1 and T9-96in vitro(IC₅₀s = 40.29 and 33.57 μM, respectively).¹Deacetylanisomycin is cytotoxic to LU99 lung carcinoma and MCF-7 breast cancer cells (IC₅₀s = 23 and 34 μM, respectively). It has been used as a negative control for assessment of protein synthesis inhibitor activity in molluscan neurons.³

1.Ekong, R.M., Kirby, G.C., Patel, G., et al.Comparison of the in vitro activities of quassinoids with activity against Plasmodium falciparum, anisomycin and some other inhibitors of eukaryotic protein synthesisBiochem. Pharmacol.40(2)297-301(1990) 2.Hosoya, Y., Kameyama, T., Naganawa, H., et al.Anisomycin and new congeners active against human tumor cell linesJ. Antibiot. (Tokyo)46(8)1300-1302(1993) 3.Alkon, D.L., Bank, B., Naito, S., et al.Inhibition of protein synthesis prolongs Ca2+-mediated reduction of K+ currents in molluscan neuronsProc. Natl. Acad. Sci. USA84(19)6948-6952(1987)