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JTP 103237
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JTP 103237图片
规格:98%
分子量:474.52
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor
货号:ajcx27808
CAS:1883864-16-1
分子式:C24H29F3N6O
分子量:474.52
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor (IC50 = 20 - 40 nM). Displays >7000-fold selectivity for human MOGAT2 over human DGAT2. Modulates intestinal lipid absorption in mice. Decreases triglyceride, diacylglycerol and fatty acid synthesis in mouse model of fatty liver. Chronic treatment decreases hepatic triglyceride content and body weight, and improves glucose tolerance in diet-induced obese mice.


Okuma et al (2015) JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity. Eur.J.Pharmacol. 758 72 PMID:25857225 |Okuma et al (2015) JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis. J.Pharmacol.Sci. 128 150 PMID:26215699