JF-NP-26 是 raseglurant 的无活性光笼衍生物，是第一个笼状 mGlu5 受体负变构调节剂。
货号:ajcx27676
CAS:N/A
分子式:C30H28FN3O4
分子量：513.56
溶解度:Soluble in DMSO
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Caged Raseglurant . Releases raseglurant upon exposure to 405 nm (violet) light. Inhibits the effects of Quisqualate in cultured neurons when exposed to 405 nm light. Exhibits analgesic activity in pain models in vivo on photoactivation. Quantum yield = 0.18.

Font et al (2017) Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator. eLIFE 6 e23545 PMID:28395733