Pep 2-8 是一种 PCSK9 抑制剂，结合 KD 为 0.7 μM，IC50 为 1.4 μM。
货号:ajcx27580
CAS:1541011-97-5
分子式:C83H110N16O24
分子量：1715.88
溶解度:Soluble 2mg/mL in PBS (pH 7.4)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. Potent inhibitor of PCSK9 binding to LDL receptor (IC50 = 0.8 μM). Restores LDL uptake in HepG2 cells treated with PCSK9.

Zhang et al (2014) Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor. J.Biol.Chem. 289 942 PMID:24225950