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UoS 12258
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
UoS 12258图片
规格:98%
分子量:334.41
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
Positive allosteric modulator of AMPA receptors
货号:ajcx27546
CAS:875927-64-3
分子式:C17H19FN2O2S
分子量:334.41
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Positive allosteric modulator of AMPA receptors (pEC50 = 5.2 for potentiation of AMPA-mediated currents in vitro). Also potentiates AMPA-mediated synaptic responses in vivo. Improves performance of rats in various learning and memory paradigms


Ward et al (2010) Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator. J.Med.Chem. 53 5801 PMID:20614889 |Ward et al (2017) Pharmacological characterization of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2, 3-dihydro-1H-inden-2-yl]-2-propanesulfonamide: a novel, clinical AMPA receptor positive allosteric modulator. Br.J.Pharmacol. 174 370 PMID:28009436