SM 324405 是一种 TLR7 激动剂前药 (EC50 \u003d 50 nM)，对人 TLR7 和大鼠 TLR7 的 pEC50 值分别为 7.3 和 6.6。
货号:ajcx27048
CAS:677773-91-0
分子式:C19H23N5O4
分子量：385.42
溶解度:DMSO: 100 mM
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Potent TLR7 agonist (EC50 = 50 nM). Exhibits selectivity for TLR7 over TLR8. Induces IFN-α and -γ expression in human PBMCs and mouse splenocytes, and inhibits IL-5 production in human PBMCs in vitro. Rapidly metabolized to acid metabolite (t½ = 2.6 min in human plasma).

Kurimoto et al (2010) Synthesis and biological evaluation of 8-oxoadenine derivatives as toll-like receptor 7 agonists introducing the antedrug concept. J.Med.Chem. 53 2964 PMID:20232824 |Biffen et al (2012) Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity. Br.J.Pharmacol. 166 573 PMID:22122192