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MRS 1477
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MRS 1477图片
规格:98%
分子量:389.51
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
TRPV1 positive allosteric modulator
货号:ajcx26980
CAS:212200-21-0
分子式:C21H27NO4S
分子量:389.51
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

TRPV1 positive allosteric modulator. Potentiates vanilloid and proton activation of TRPV1 channels. Exhibits analgesic effects in combination with capsaicin in rats. Also prolongs capsaicin-induced hypothermia in mice.


Kaszas et al (2012) Small molecule positive allosteric modulation of TRPV1 activation by vanilloids and acidic pH. J.Pharmacol.Exp.Ther. 340 152 PMID:22005042 |Lebovitz et al (2012) Positive allosteric modulation of TRPV1 as a novel analgesic mechanism. Mol.Pain 8 PMID:22998799 |Roh et al (2008) Structure-activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1). Bioorg.Med.Chem. 16 9349 PMID:18809334