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BIRT 377
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
BIRT 377图片
规格:98%
分子量:442.13
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品介绍
BIRT 377 是一种有效的口服生物利用度抑制剂,可抑制细胞间粘附分子-1 (ICAM-1) 和淋巴细胞功能相关抗原-1 (LFA-1) 之间的相互作用,Ki 为 25.8 nM。
货号:ajcx26880
CAS:213211-10-0
分子式:C18H15BrCl2N2O2
分子量:442.13
溶解度:Soluble in DMSO
纯度:98%
存储:Store at -20°C
库存:现货

Background:

Potent negative allosteric modulator of LFA-1 (lymphocyte function-associated antigen-1) (Kd = 26 nM). Binds to the I-domain of LFA-1. Reversibly inhibits LFA-1 mediated binding of SKW3 leukemia cells to ICAM-1. Inhibits superantigen (SEB)-induced IL-2 production from lymphocytes in vitro and attenuates the SEB-induced increase in IL-2 plasma levels in a mouse model in vivo. Orally available.


Kelly et al (1999) Cutting edge: a small molecule antagonist of LFA-1-mediated cell adhesion. J.Immunol. 163 5173 PMID:10553036 |Wu et al (2004) Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-alpha]imidazol-2-one derivatives. J.Med.Chem. 47 5356 PMID:15481974 |Last-Barney et al (2001) Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction. J.Am.Chem.Soc. 123 5643 PMID:11403595