Tamsulosin hydrochloride ((R)-(-)-YM12617) 是 α1-adrenergic receptor 的抑制剂。
货号:ajcx26800
CAS:106463-17-6
分子式:C20H28N2O5S.HCl
分子量：444.97
溶解度:DMSO: 2 mg/ml,DMSO:PBS (pH 7.2)(1:9): 0.10 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Selective α1A-adrenoceptor antagonist (pKi values are 9.97, 9.64 and 8.86 for α1A, α1B and α1D subtypes respectively). Decreases resting maximal urethral pressure with negligable effect on mean arterial blood pressure in vivo.

Garcia-Sainz et al (1995) Alpha 1-adrenoceptor subtype selectivity of tamsulosin: studies using livers from different species. Eur.J.Pharmacol. 289 1 PMID:7781702 |Taguchi et al (1997) Effects of tamsu. metabolites at alpha-1 adrenoceptor subtypes. J.Pharmacol.Exp.Ther. 280 1 PMID:8996174 |Ohtake et al (2005) Effects of tamsu. on resting urethral pressure and arterial blood pressure in anaesthetized female dogs. J.Pharm.Pharmacol. 58 345