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1,1&rsquo-Ethylidene-bis-(L-tryptophan)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
1,1&rsquo-Ethylidene-bis-(L-tryptophan)图片
规格:98%
分子量:434.5
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
A potential impurity found in commercial preparations of L-tryptophan
货号:ajcx26462
CAS:132685-02-0
分子式:C24H26N4O4
分子量:434.5
溶解度:1 M NaOH: soluble
纯度:98%
存储:Store at -20°C
库存:现货

Background:

1,1’-Ethylidene-bis-(L-tryptophan) is a potential impurity found in commercial preparations of L-tryptophan.1It increases the proliferation of EoL-3 eosinophilic leukemia cells, release of eosinophil cationic protein from isolated human peripheral blood eosinophils, and IL-5 production in isolated human T cells.21,1’-Ethylidene-bis-(L-tryptophan) (40 µg/kg) induces fascia thickening and increases mast cell infiltration, inflammation, and fibrosis in superficial adipose and panniculus carnosus tissues in mice as a model system of eosinophilia-myalgia syndrome.3

1.Trucksess, M.W.Separation and isolation of trace impurities in L-tryptophan by high-performance liquid chromatographyJ. Chromatogr.630(1-2)147-150(1993) 2.Yamaoka, K.A., Miyasaka, N., Inuo, G., et al.1,1’-Ethylidenebis(tryptophan) (Peak E) induces functional activation of human eosinophils and interleukin 5 production from T lymphocytes: Association of eosinophilia-myalgia syndrome with a L-tryptophan contaminantJ. Clin. Immunol.14(1)50-60(1994) 3.Love, L.A., Rader, J.I., Crofford, L.J., et al.Pathological and immunological effects of ingesting L-tryptophan and 1,1’-ethylidenebis (L-tryptophan) in Lewis ratsJ. Clin. Invest.91(3)804-811(1993)