A long-chain atypical ceramide
货号:ajcx19798
CAS:N/A
分子式:C40H79NO2
分子量：606.1
溶解度:DMF: >20 mg/ml,DMSO: >20 mg/ml,Ethanol: >30mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.5 mg/ml,PBS (pH 7.2):<50µ g/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

C22 1-deoxyceramide (m18:1(14Z)/22:0) is a long-chain atypical ceramide containing a 1-deoxysphingosine (m18:1(14Z)) backbone with a cis double bond at the 14-15 position rather than a trans double bond at the 4-5 position. 1-Deoxysphingolipids are formed when serine palmitoyltransferase condenses palmitoyl-CoA with alanine instead of serine during sphingolipid synthesis.1,2

|1. Steiner, R., Saied, E.M., Othman, A., et al. Elucidating the chemical structure of native 1-deoxysphingosine. J. Lipid Res. 57(7), 1194-1203 (2016).|2. Alecu, I., Othman, A., Penno, A., et al. Cytotoxic 1-deoxysphingolipids are metabolized by a cytochrome P450-dependent pathway. J. Lipid Res. 58(1), 60-71 (2017).