| 规格: | 98% |
| 分子量: | 2392.8 |
| 包装 | 价格(元) |
| 500ug | 电议 |
| 1mg | 电议 |
Background:
Amyloid-β (Aβ) (17-40) is a 24-residue fragment of the Aβ protein that is formed via post-translational processing of amyloid precursor protein (APP) by α- and γ-secretases. In vitro, Aβ (17-40) polymerizes into lattice-like structures that do not bind thioflavin T. It inhibits interactions between fibrinogen and biotinylated Aβ (1-42) as well as between cholesterol and apolipoprotein E (ApoE) with IC50 values of 13.4 and 25 μM, respectively. Aβ (17-40) increases the rate of Aβ (1-40) aggregation in vitro when used at an equimolar concentration. Aβ (17-40) (25 μM) induces cell death in cultured rat hippocampal neurons.
m.cnreagent.com