TDRL-551 是一种有效的复制蛋白A (RPA) 抑制剂 (IC50=18 ?M)。TDRL-551 抑制 RPA-DNA 相互作用，提高以铂为基础的肺癌和卵巢癌化疗的疗效。RPA 在核苷酸切除修复 (NER) 和同源重组 (HR) 中起着至关重要的作用，在 DNA 复制和 DNA 损伤检查点激活中也起着重要作用。
货号:ajcx37816
CAS:1644626-43-6
分子式:C25H23ClIN3O4
分子量：591.83
溶解度:DMSO : 62.5 mg/mL (105.60 mM; Need ultrasonic)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 µM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation[1].

[1]. Mishra AK, et al. Chemical inhibitor targeting the replication protein A-DNA interaction increases the efficacy of Pt-based chemotherapy in lung and ovarian cancer. Biochem Pharmacol. 2015;93(1):25-33.