RO5256390 is a novel and potent TAAR1 (trace amine-associated receptor 1) agonist. RO5256390 blocks psychostimulant-induced hyperactivity and produces a brain activation pattern reminiscent of the antipsychotic drug olanzapine, suggesting antipsychotic-like properties. TAAR1 activation promotes vigilance in rats and shows pro-cognitive and antidepressant-like properties in rodent and primate models. TAAR1 agonists may provide a novel and differentiated treatment of schizophrenia as compared with current TAAR1 agonists may improve not only the positive symptoms but also the negative symptoms and cognitive deficits, without causing adverse effects such as motor impairments or weight gain.

纯度：≥98%

CAS：1043495-96-0