Leucettamol A is a A leukotriene B4 receptor antagonist extracted from the marine sponge Leucetta microraphis.It has a structure of a chiral long-chain "two-headed" sphingolipid (dimeric sphingolipid). It inhibits the formation of a complex composed of the ubiquitin E2 enzyme Ubc13 and Uev1A. The post-translational modification of proteins with ubiquitin (Ub) controls a number of fundamental processes within the cell, including protein degradation by the Ub–proteasome system (UPS). These inhibitors may be leads for anti-cancer agents and anti-rheumatoid arthritis agents. References: Chen H, Wu G, Gao S, Guo R, Zhao Z, Yuan H, Liu S, Wu J, Lu X, Yuan X, Yu Z, Zu X, Xie N, Yang N, Hu Z, Sun Q, Zhang W. Discovery of Potent Small-Molecule Inhibitors of Ubiquitin-Conjugating Enzyme UbcH5c from α-Santonin Derivatives. J Med Chem. 2017 Aug 2. doi: 10.1021/acs.jmedchem.6b01829. [Epub ahead of print] PubMed PMID: 28696694.

纯度：≥98%

CAS：151124-32-2