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LDC3140
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1453833-30-1
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

LDC3140, formerly known as LDC043140, is a potent CDK7 inhibitor. Cyclin-dependent kinase 7 (CDK7) activates cell cycle CDKs and is a member of the general transcription factor TFIIH. Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells. References: Kelso TW, Baumgart K, Eickhoff J, Albert T, Antrecht C, Lemcke S, Klebl B, Meisterernst M. Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cells. Mol Cell Biol. 2014 Oct 1;34(19):3675-88. doi: 10.1128/MCB.00595-14. Epub 2014 Jul 21. PubMed PMID: 25047832; PubMed Central PMCID: PMC4187722.

纯度:≥98%

CAS:1453833-30-1