您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > RP-72540
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
RP-72540
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:139088-45-2
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

RP-72540, formerly known as RPR-102681, is a cholecystokinin B receptor antagonist potentially for the treatment of cocaine abuse. RP 72540 showed selectivity factors in express of 200 for CCKB versus CCKA receptors and also had high affinity for gastrin binding sites in the stomach. Administration of RP-72540 resulted in a dose-dependent inhibition of [3H]pCCK-8 binding in mouse brain homogenate. However, the relative penetration of RP-72540 into the forebrain after peripheral administration was below 0.01%. References: Bertrand P, Bohme GA, Durieux C, Guyon C, Capet M, Jeantaud B, Boudeau P, Ducos B, Pendley CE, Martin GE, et al. Pharmacological properties of ureido-acetamides, new potent and selective non-peptide CCKB/gastrin receptor antagonists. Eur J Pharmacol. 1994 Sep 12;262(3):233-45. PubMed PMID: 7813588.

纯度:≥98%

CAS:139088-45-2