您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > RQ-00311651
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
RQ-00311651
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1257116-00-9
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

RQ-00311651 is a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain. RQ-00311651 strongly suppressed T currents when tested at holding potentials of -65 ~ -60 mV, but not -80 mV, in the Cav3.1- or Cav3.2-expressing cells. RQ-00311651 also inhibited high K-induced Ca signaling in those cells. References: Sekiguchi F, Kawara Y, Tsubota M, Kawakami E, Ozaki T, Kawaishi Y, Tomita S, Kanaoka D, Yoshida S, Ohkubo T, Kawabata A. Therapeutic potential of RQ-00311651, a novel T-type Ca2+ channel blocker, in distinct rodent models for neuropathic and visceral pain. Pain. 2016 Aug;157(8):1655-65. doi: 10.1097/j.pain.0000000000000565. PubMed PMID: 27023424.

纯度:≥98%

CAS:1257116-00-9