CAS NO: | 76343-94-7 |
包装: | 50mg, 100mg, 250mg |
规格: | ≥98% |
Latrunculin B causes concentration-dependent changes in cell shape and actin organization. It sequesters G-actin and prevents F-actin assembly. It binds monomeric actin 1 stoichiometry and can be used to block actin polymerization both in vitro and in cells (Kd = 60 nM).1 The short-term effects of latrunculin B are comparable to those of latrunculin A, although latrunculin B is slightly less potent.2 However, latrunculin B is gradually inactivated by serum so that induced changes are transient in the continued presence of the compound. For this reason, latrunculin B may have fewer unwanted effects than latrunculin A and may be preferred for short-term studies. Latrunculin B is a 14-membered macrolide attached to 2-thiazolidinone moiety; from Red Sea sponge Latrunculia magnifica. References: Lu YY, Lin YK, Wen ZH, Chen YC, Chen SA, Chen YJ. Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Clin Sci (Lond). 2016 May;130(9):721-32. doi: 10.1042/CS20150593. Epub 2016 Feb 2. PubMed PMID: 26839418.
纯度:≥98%
CAS:76343-94-7