靶标:
FZR1
产品别名:
CDC20C; CDH1; FZR; FZR2; HCDH; HCDH1; FZR1; fizzy and cell division cycle 20 related 1; fizzy and cell division cycle 20 related 1; fizzy-related protein homolog; CDC20 homolog 1; CDC20-like 1b; CDC20-like protein 1; cdh1/Hct1 homolog; fizzy/cell division cycle 20 related 1; 细胞分裂周期样蛋白20;
背景信息:
Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ over error-free, RBBP8-mediated homologous recombination (HR.
宿主:Rbt
类型:Pab
同种型:IgG
应用:WB
纯化方式:亲和纯化
偶联物:Unconjugated
性状:液体
存储溶液:参阅说明书
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存:经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。