Description: Laninamivir Octanoate (CS-8958, Inavir, R-125489) is a novel long-acting neuraminidase inhibitor that is a prodrug and has to be converted to the active form Laninamivir. Laninamivir inhibits avian H12N5 NA (N5), pH1N1 N1 NA (p09N1) and A/RI/5+/1957 H2N2 N2 (p57N2) with IC50s of 0.90 nM, 1.83 nM and 3.12 nM, respectively. It exhibits clinical efficacy for both treatment and prophylaxis of influenza virus infection, resulting from hydrolytic bioactivation into its pharmacologically active metabolite laninamivir in the pulmonary tissue.

References: Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition. PLoS Pathog. 2011 Oct;7(10):e1002249.

Related CAS #: 203120-46-1 (octanoate) 203120-17-6 (free base) 203120-18-7 (TFA) 1233643-88-3 (octanoate hydrate)

纯度：≥98%

CAS：203120-46-1