DDO-2117 is a potent blocker of mixed lineage leukemia 1 (MLL1)-WDR5 interaction which inhibits MLL1 complex H3K4 methyltransferase activity. References: Li DD, Chen WL, Wang ZH, Xie YY, Xu XL, Jiang ZY, Zhang XJ, You QD, Guo XK. High-affinity small molecular blockers of mixed lineage leukemia 1 (MLL1)-WDR5 interaction inhibit MLL1 complex H3K4 methyltransferase activity. Eur J Med Chem. 2016 Nov 29;124:480-489. doi: 10.1016/j.ejmech.2016.08.036. Epub 2016 Aug 20. PubMed PMID: 27598236.
纯度:≥98%