L-759,656 is highly selective CB2 receptor agonist (Kis are 11.8 and 4888 nM for CB2 and CB1 receptors respectively). L-759,656 potently inhibits forskolin-stimulated cAMP production via CB2 receptors expressed in CHO cells (EC50 = 3.1 nM). References: Taylor L, Christou I, Kapellos TS, Buchan A, Brodermann MH, Gianella-Borradori M, Russell A, Iqbal AJ, Greaves DR. Primary Macrophage Chemotaxis Induced by Cannabinoid Receptor 2 Agonists Occurs Independently of the CB2 Receptor. Sci Rep. 2015 Jun 2;5:10682. doi: 10.1038/srep10682. PubMed PMID: 26033291; PubMed Central PMCID: PMC4451551.
纯度:≥98%
CAS:174627-56-6