PRRC2B (Proline-Rich Coiled-Coil 2B) is a Protein Coding gene. The PRRC2B gene, located on 9q34.13, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. PRRC2B is a conservative gene that is found in the genomes of most vertebrates and is widely expressed in the brain, ovary, and other tissues. Immunohistochemical staining showed that PRRC2B was located in the plasma and neurites of neurons with big size. Diseases associated with PRRC2B include Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 2, and Spinocerebellar Ataxia 36. An important paralog of this gene is PRRC2C. 228 organisms have orthologs with human gene PRRC2B.