SB-706375 is a high affinity, non-peptide antagonist of the urotensin-II (UT) receptor. SB-706375 exhibits high affinity for mammalian UT receptors, including human, mouse and rat (Kis are 9.3, 19.1 and 20.7 nM respectively, in HEK293 cells expressing recombinant UT receptors). References: Forty EJ, Ashton N. The urotensin system is up-regulated in the pre-hypertensive spontaneously hypertensive rat. PLoS One. 2013 Dec 5;8(12):e83317. doi: 10.1371/journal.pone.0083317. eCollection 2013. PubMed PMID: 24340095; PubMed Central PMCID: PMC3855556.

纯度：≥98%

CAS：733734-61-7