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KRX-0601
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
KRX-0601图片
CAS NO:112953-11-4
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍

KRX-0601 (UCN-01; KRX0601; 7-hydroxystaurosporine) is a synthetic staurosporine analog with antibiotic and anticancer activity, acting by inhibiting many phosphokinases such as serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases, resulting in accumulation of cells in the G1 phase and induction of apoptosis. UCN-01 also enhances the cytotoxicity of other anti-cancer drugs, such as DNA-damaging agents and anti-metabolite drugs. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis.

纯度:≥98%

CAS:112953-11-4