重组FCGR2B蛋白

立即咨询

重组FCGR2B蛋白

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

产品名称

Recombinant FCGR2B
Recombinant Fc gamma receptor IIb protein

产品介绍

基因名：

FCGR2B

产品别名：

CD32； CD32B； FCG2； FCGR2； FCGR2C； FcGRIIB； FcRII-c； FcgammaRIIb； IGFR2； FCGR2B； Fc gamma receptor IIb； Fc gamma receptor IIb； low affinity immunoglobulin gamma Fc region receptor II-b； CDw32； Fc fragment of IgG receptor IIb； Fc fragment of IgG, low affinity II, receptor for (CD32)； Fc fragment of IgG, low affinity IIb, receptor (CD32)； Fc fragment of IgG, low affinity IIb, receptor for (CD32)； Fc gamma RIIb； Fc-gamma RII-c； Fc-gamma-RIIc； IgG Fc receptor II-c； Low affinity immunoglobulin gamma Fc region receptor II-c； fc-gamma RII-b； fc-gamma-RIIb； fcRII-b； igG Fc receptor II-b；

背景信息：

FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG. The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM) and delivers an inhibitory signal upon ligand binding. Ligation of FcγRIIB on B cells down-regulates antibody production and in some circumstances may promote apoptosis. Co-ligation of FcγRIIB on dendritic cells inhibits maturation and blocks cell activation. FcγRIIB may also be a target for monoclonal antibody therapy for malignancies. FcγRIIB plays an important negative-regulating role through modulating the signals from activation receptors.

标签：His-tag
分类：Recombinant
类型：Protein
偶联物：Unconjugated
内毒素水平：按批次，参阅瓶身标签
性状:Liquid
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型：purified
内含物：不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存：2-8°C不超过一个月，-80°C不超过12个月。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。