基因名：
HSD17B1
产品别名：
17-beta-HSD； 20-alpha-HSD； E2DH； EDH17B2； EDHB17； HSD17； SDR28C1； HSD17B1； hydroxysteroid 17-beta dehydrogenase 1； hydroxysteroid 17-beta dehydrogenase 1； 17-beta-hydroxysteroid dehydrogenase type 1； 17-beta-HSD 1； 20 alpha-hydroxysteroid dehydrogenase； estradiol 17-beta-dehydrogenase 1； placental 17-beta-hydroxysteroid dehydrogenase； short chain dehydrogenase/reductase family 28C member 1； short chain dehydrogenase/reductase family 28CE, member 1； 17-β-羟基类固醇脱氢酶1(HSD17b1)； 羟类固醇脱氢酶17β； 羟类固醇脱氢酶17β-HSD；
背景信息：
This gene encodes a member of the 17beta-hydroxysteroid dehydrogenase family of short-chain dehydrogenases/reductases. It has a dual function in estrogen activation and androgen inactivation and plays a major role in establishing the estrogen E2 concentration gradient between serum and peripheral tissues. The encoded protein catalyzes the last step in estrogen activation, using NADPH to convert estrogens E1 and E2 and androgens like 4-androstenedione, to testosterone. It has an N-terminal short-chain dehydrogenase domain with a cofactor binding site, and a narrow, hydrophobic C-terminal domain with a steroid substrate binding site. This gene is expressed primarily in the placenta and ovarian granulosa cells, and to a lesser extent, in the endometrium, adipose tissue, and prostate. Polymorphisms in this gene have been linked to breast and prostate cancer. A pseudogene of this gene has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
标签：His-tag
分类：Recombinant
类型：Protein
偶联物：Unconjugated
内毒素水平：按批次，参阅瓶身标签
性状:Liquid
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型：purified
内含物：不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存：2-8°C不超过一个月，-80°C不超过12个月。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
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