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重组NK细胞抑制性受体2DL1蛋白
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。

产品名称
重组杀伤细胞免疫球蛋白样受体2DL1(KIR2DL1)
Recombinant KIR2DL1
产品介绍
基因名:

KIR2DL1


产品别名:

CD158A; KIR-K64; KIR221; KIR2DL3; NKAT; NKAT-1; NKAT1; p58.1; KIR2DL1; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1; killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1; killer cell immunoglobulin-like receptor 2DL1; CD158 antigen-like family member A; KIR2DL protein; KIR2DL1/3DL2; MHC class I NK cell receptor; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1; killer inhibitory receptor 2-2-1; natural killer-associated transcript 1; p58 NK cell inhibitory receptor NKR-K6; p58 NK receptor CL-42/47.11; p58 killer cell inhibitory receptor KIR-K64; p58 natural killer cell receptor clones CL-42/47.11; p58.1 MHC class-I-specific NK receptor; NK细胞抑制性受体2DL1; 杀伤细胞免疫球蛋白样受体2DL1(KIR2DL1);


背景信息:
Killer cell immunoglobulin-like receptor 2DL1 or KIR2DL1 is an inhibitory Natural Killer cell immunoglobulin-like receptor with two extracellular immunoglobulin domains. KIR2DL1 is a member of the Killer cell immunoglobulin-like receptor family whose members are classified by the number of the extracellular immunoglobulin domains and the length of the cytoplasm domain. KIR2DL1 is a transmembrane glycoprotein expressed by natural killer cells and subsets of T cells. KIR2DL1 down-regulates the cytotoxicity of NK cells upon recognition of specific class I major histocompatibility complex (MHC) molecules on target cells. It has been reported that the KIR2DL1 is bound to its class I MHC ligand, HLA-Cw4. The KIR2DL1-HLA-Cw4 interface exhibits charge and shape complementarity. Specificity is mediated by a pocket in KIR2DL1 that hosts the Lys80 residue of HLA-Cw4. Many residues conserved in HLA-C and KIR2DL receptors make different interactions in KIR2DL1-HLA-Cw4 and a previously reported KIR2DL2-HLA-Cw3 complex. A dimeric aggregate of KIR-HLA-C complexes was observed in one KIR2DL1-HLA-Cw4 crystal.

标签:His-tag   
分类:Recombinant  
类型:Protein   
偶联物:Unconjugated
内毒素水平:按批次,参阅瓶身标签
性状:Liquid
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型:purified
内含物:不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存:2-8°C不超过一个月,-80°C不超过12个月。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。