基因名:
RASA1
产品别名:
CM-AVM; CMAVM; CMAVM1; GAP; PKWS; RASA; RASGAP; p120; p120GAP; p120RASGAP; RASA1; RAS p21 protein activator 1; RAS p21 protein activator 1; ras GTPase-activating protein 1; RAS p21 protein activator (GTPase activating protein) 1; p120 RAS GTPase activating protein; triphosphatase-activating protein; Rho GTP酶激活蛋白1/血管畸形骨肥大综合征相关蛋白; 磷酸化Rho GTP酶激活蛋白1/血管畸形骨肥大综合征相关蛋白;
背景信息:
The mammalian c-H-, c-K- and N-Ras proto-oncogenes encode ubiquitously expressed proteins (1,2). p21Ras can exist in either a physiologically quiescent GDP-binding state or a GTP-binding signal-emitting state (3). Oncogenic p21Ras proteins are trapped in the excited signal-emitting state because the mechanism normally employed to delimit their excitation period, hydrolysis of their bound GTP to GDP, is impaired as a result of specific mutations (3). Interaction of p21Ras with GTPase activating protein (GAP) can increase hydrolysis of p21Ras-bound GTP by as much as 1000-fold (4,5). The product of the neurofibromatosis type 1 gene (NF1) has also been shown to exhibit p21Ras GAP activity (6,7), and proteins that stimulate the GTPase activity of three other low molecular weight GTPases, including Rho, Rab 3A and Rap 1, have also been described (8,9).
标签:His-tag
分类:Recombinant
类型:Protein
偶联物:Unconjugated
内毒素水平:按批次,参阅瓶身标签
性状:Liquid
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型:purified
内含物:不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存:2-8°C不超过一个月,-80°C不超过12个月。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。