JTV-803 is a factor Xa inhibitor potentially for the treatment of thrombosis. JTV-803 showed a competitive inhibitory effect on human factor Xa, with a K(i) value of 0.019 microM. JTV-803 was 100 times more selective in inhibiting human factor Xa as compared to its inhibitory activity against thrombin, plasmin, and trypsin. JTV-803 exerted a potent inhibitory effect on human factor Xa (IC(50): 0.081 microM). JTV-803 prolonged activated partial thromboplastin time and prothrombin time in a dose-dependent manner. References: Gerotziafas GT, Samama MM. Heterogeneity of synthetic factor Xa inhibitors. Curr Pharm Des. 2005;11(30):3855-76. Review. PubMed PMID: 16305517.

纯度：≥98%

CAS：247131-79-9