KDM5-C49 is a potent and selective inhibitor of KDM5 (formerly known as JARID1). KDM5-C49 exhibits 25-100-fold selectivity between KDM5B and KDM6B. Members of the KDM5 (formerly known as JARID1) family regulate cell proliferation and stem cell self-renewal and differentiation. References: Johansson C, Velupillai S, Tumber A, Szykowska A, Hookway ES, Nowak RP, Strain-Damerell C, Gileadi C, Philpott M, Burgess-Brown N, Wu N, Kopec J, Nuzzi A, Steuber H, Egner U, Badock V, Munro S, LaThangue NB, Westaway S, Brown J, Athanasou N, Prinjha R, Brennan PE, Oppermann U. Structural analysis of human KDM5B guides histone demethylase inhibitor development. Nat Chem Biol. 2016 Jul;12(7):539-45. doi: 10.1038/nchembio.2087. Epub 2016 May 23. PubMed PMID: 27214403.

纯度：≥98%

CAS：1596348-16-1