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重组β-1,3-葡糖醛酸基移酶1(b3GAT1)蛋白
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。

产品名称
重组β-1,3-葡糖醛酸基移酶1(b3GAT1)真核蛋白
Recombinant B3GAT1
产品介绍
基因名:

B3GAT1


产品别名:

CD57; GLCATP; GLCUATP; HNK1; LEU7; NK-1; NK1; B3GAT1; beta-1,3-glucuronyltransferase 1; beta-1,3-glucuronyltransferase 1; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1; LEU7 antigen; UDP-GlcUA:glycoprotein beta-1,3-glucuronyltransferase; glucuronosyltransferase P; β-1,3-葡糖醛酸基移酶1(b3GAT1); β-1,3-葡糖醛酸基移酶1(b3GAT1)真核蛋白; 髓鞘相关糖蛋白(CD57);


背景信息:
B3GAT1 is the key enzyme during the biosynthesis of the carbohydrate epitope HNK-1, which is present on a number of cell adhesion molecules important in neurodevelopment. It adds a glucuronic residue to the terminal lactosamine residue (Gal beta 14GlcNAc) of a glycoprotein or glycolipid, which can be further sulfated to become the HNK1 epitope, a unique trisaccharide structure, HSO3-3GlcA beta 1-3Gal beta 1-4GlcNAc. The enzyme activity was found to be enhanced in the presence of sphingomyelin and phosphatidylinositol. The HNK1 carbohydrate epitope is characteristically expressed on a series of cell adhesion molecules in addition to some glycolipids in the extracellular matrix and on the cell surface in the nervous system, where it is involved in cell-cell and cell-substratum interaction and recognition during the development of the nervous system. Like most known glycosyltransferases, B3GAT1 is a type II Golgi-resident transmembrane protein with a short N-terminal cytoplasmic domain and a single pass transmembrane domain followed by an enzymatic domain in the lumen of Golgi apparatus. The enzyme activity was assayed using a phosphatase-coupled method.

标签:His-tag   
分类:Recombinant  
类型:Protein   
偶联物:Unconjugated
内毒素水平:按批次,参阅瓶身标签
性状:Liquid
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型:purified
内含物:不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存:2-8°C不超过一个月,-80°C不超过12个月。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。