EDC3 is associated with an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005 [PubMed 16364915]).[supplied by OMIM, Mar 2008]
Edc3, enhancer of mRNA-decapping protein 3, is a 508 amino acid protein that maps to human gene EDC3. Edc3 is a member of the EDC3 family and contains one YjeF N-terminal domain. Edc3 is localized to the cytoplasm and is found primarily in the processing bodies (PBs) of the cell. Evidence indicates Edc3 also interacts with TTP (zinc finger protein 36), a candidate gene for obesity-related metabolic complications.