| CAS NO: | 60200-06-8 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| 2g | 电议 |
| Molecular Weight (MW) | 380.66 |
|---|---|
| Formula | C8H8Cl3N3O4S2 |
| CAS No. | 60200-06-8 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 76 mg/mL (199.7 mM) |
| Water: <1 mg/mL | |
| Ethanol: 7 mg/mL (18.4 mM) | |
| Solubility (In vivo) | 1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL |
| Synonyms | MK 401; MK-401; MK401; L-631529; L631529; L 631529; L-631,529; L631,529; L 631,529; Clorsulone; Clorsulonum; BRN 2821757; BRN2821757; BRN-2821757 |
| In Vitro | In vitro activity: Clorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep. Target: Antiparasitic Clorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. |
|---|---|
| In Vivo | Clorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation. |
| Animal model | Rat |
| Formulation & Dosage | Formulated in 1:2 mixture of polyethylene glycol 400:dimethyl sulphoxide; 12.5 mg/kg; p.o. |
| References | J Med Chem. 1977 Sep;20(9):1225-7; Mol Biochem Parasitol. 1982 Mar;5(3):133-45; Parasitol Res. 2004 Feb;92(3):232-41. |
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