JIB-04 Z-isomer, formerly known as NSC 693627, is the Z-configurational isomer of JIB-04 which is a potent and pan-selective Jumonji histone demethylase inhibitor with IC50s of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D, respectively.. JIB-04 selectively blocks cancer cell growth in vitro and diminishes tumor growth in H358 and A549 mouse xenograft models in vivo. JIB-04 can prolong survival in a mouse model of breast cancer. In a sensitive ELISA assay, JIB-04 inhibits JARID1A, 2A, 2B, 2C, 2E and 3 with IC50 values of 230nM, 445nM, 435nM, 1100nM, 340nM and 855nM, respectively. Among the JMJD2 family, JMJD2D has highest sensitivity.

纯度：≥98%

CAS：199596-24-2