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重组组蛋白H4 K20甲基转移酶
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。

产品名称
Recombinant Kmt5a
Recombinant lysine methyltransferase 5A protein
产品介绍
基因名:

Kmt5a


产品别名:

2410195B05Rik; AA617402; AW536475; PR-SET7; PR/SET07; Setd8; Kmt5a; lysine methyltransferase 5A; lysine methyltransferase 5A; N-lysine methyltransferase KMT5A; H4-K20-HMTase KMT5A; H4-K20-HMTase SETD8; N-lysine methyltransferase SETD8; PR/SET domain-containing protein 07; SET domain containing (lysine methyltransferase) 8; SET domain-containing protein 8; histone-lysine N-methyltransferase KMT5A; histone-lysine N-methyltransferase SETD8; lysine-specific methylase 5A; 组蛋白H4 K20甲基转移酶;


背景信息:
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes.

标签:His-tag   
分类:Recombinant  
类型:Protein   
偶联物:Unconjugated
内毒素水平:按批次,参阅瓶身标签
性状:Liquid
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型:purified
内含物:不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存:2-8°C不超过一个月,-80°C不超过12个月。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。