Simotaxel, also known TL-909 and MST-997, is an orally bioavailable taxane with superior in vitro and in vivo efficacy in paclitaxel- and docetaxel-resistant tumor models. MST-997 induced microtubule polymerization (EC50 = 0.9 micromol/L) and bundling, resulting in G2-M arrest and apoptosis. In addition, MST-997 was a potent inhibitor of paclitaxel- and docetaxel-sensitive tumor cell lines that did not have detectable P-glycoprotein (IC50 = 1.8 +/- 1.5 nmol/L). References:

纯度：≥98%

CAS：791635-59-1