Description: Flecainide (Tambocor) is a potent class Ic antiarrhythmic drug used in managing certain situations to prevent serious heart rhythm disorders or supraventricular arrhythmia. It works by blocking Nav1.5 sodium channels, which play a major part in the heart's electrical activity, thus causing prolongation of the cardiac action potential. When the heart is firing too quickly in an abnormal rhythm (arrhythmia), flecainide slows down the electricity to help the rhythm return to normal.

References:

[1]. Flecainide inhibits the transient outward current in atrial myocytes isolated from the rabbit heart. J Pharmacol Exp Ther. 1995 Jul;274(1):315-21.

[2]. Different flecainide sensitivity of hNav1.4 channels and myotonic mutants explained by state-dependent block. J Physiol. 2004 Jan 15;554(Pt 2):321-34.

[3]. Oral flecainide is effective in management of refractory tachycardia in infants. Indian Heart J. 2013 Mar-Apr;65(2):168-71.

Related CAS: 54143-56-5 (acetate); 54143-55-4 (free base)

纯度：≥98%

CAS：54143-55-4