JAK3i is a selective covalent inhibitor of JAK3 kinase activity. It reveals two distinct temporally bioavailable waves of STAT5 phosphorylation and more potently targets the second wave, which is required for cell cycle progression and T cell proliferation. References: Smith GA, Uchida K, Weiss A, Taunton J. Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling. Nat Chem Biol. 2016 May;12(5):373-9. doi: 10.1038/nchembio.2056. Epub 2016 Mar 28. PubMed PMID: 27018889; PubMed Central PMCID: PMC4837022.
纯度:≥98%
CAS:1918238-72-8