Description: Isatoribine (immunosine, or 7-thia-8-oxoguanosine) is a novel and potent guanosine analog showing immunostimulatory activity in vivo and in vitro. It acts on different components of the immune system including B cells, natural killer (NK) cells and antigen-presenting cells (APC). It was found that immunosine significantly stimulates proliferation of T cells. The effect was dose-dependent and also depended on concentrations of specific stimulators. Maximal stimulation was seen using 250 microM immunosine.

References: Xiang AX, Webber SE, Kerr BM, Rueden EJ, Lennox JR, Haley GJ, Wang T, Ng JS, Herbert MR, Clark DL, Banh VN, Li W, Fletcher SP, Steffy KR, Bartkowski DM, Kirkovsky LI, Bauman LA, Averett DR. Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine. Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):635-40. PubMed PMID: 18066870.

Related CAS #: 198832-38-1 (hydrate) 122970-40-5 (free base)

纯度：≥98%

CAS：198832-38-1