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SN-28049
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:492472-30-7
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

SN-28049 SN is a DNA intercalating drug that binds selectively to GC-rich DNA and shows curative activity against the Colon 38 adenocarcinoma in mice. SN 28049 has a complex action that may involve poisoning of topo IIalpha, suppression of topo I and inhibition of gene transcription from promoters with SP-1 sites. These actions may contribute to the promising experimental solid tumour anticancer activity of SN 28049. References: Lukka PB, Paxton JW, Kestell P, Baguley BC. Comparison of a homologous series of benzonaphthyridine anti-cancer agents in mice: divergence between tumour and plasma pharmacokinetics. Cancer Chemother Pharmacol. 2012 Jul;70(1):151-60. doi: 10.1007/s00280-012-1892-0. Epub 2012 Jun 3. PubMed PMID: 22660735.

纯度:≥98%

CAS:492472-30-7