SNAP-5114 is a GABA transport inhibitor. It shows selectivity for GAT-3 and GAT-2 (IC50 are 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1 respectively). SNAP-5114 increases thalamic GABA levels and is an anticonvulsant following systemic administration in vivo. References: Pabel J, Faust M, Prehn C, Worlein B, Allmendinger L, Hofner G, Wanner KT. Development of an (S)-1-{2-[tris(4-methoxyphenyl)methoxy]ethyl}piperidine-3-carboxylic acid [(S)-SNAP-5114] carba analogue inhibitor for murine γ-aminobutyric acid transporter type 4. ChemMedChem. 2012 Jul;7(7):1245-55. doi: 10.1002/cmdc.201200126. Epub 2012 Apr 27. PubMed PMID: 22544452.

纯度：≥98%

CAS：157604-55-2