JI130 is an inhibitor of the cancer-associated transcription factor Hes1 via the PHB2 chaperone. JI130 stabilizes PHB2's interaction with Hes1 outside the nucleus, inducing G2/M cell cycle arrest. References: Perron A, Nishikawa Y, Iwata J, Shimojo H, Takaya J, Kobayashi K, Imayoshi I, Mbenza NM, Takenoya M, Kageyama R, Kodama Y, Uesugi M. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294. doi: 10.1074/jbc.RA118.002316. Epub 2018 Mar 9. PubMed PMID: 29523683; PubMed Central PMCID: PMC5971435.

纯度：≥98%

CAS：2234271-86-2