SP-4206 is a IL-2Ralpha inhibitor. SP4206 (Kd approximately 70 nM) was found to block binding of the IL-2alpha receptor (IL-2Ralpha) to IL-2 (Kd approximately 10 nM). Mutational studies show that SP4206 targets virtually the same critical "hot-spot" residues on IL-2 that drive binding of IL-2Ralpha. Moreover, a mutation that enhances binding to the IL-2Ralpha near these hot spots also enhances binding to SP4206. References:

纯度：≥98%

CAS：515846-21-6