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GKT137831
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GKT137831图片
CAS NO:1218942-37-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
10mM * 1mL in DMSO电议

产品名称
GKT-137831, GKT 137831
产品介绍

生物活性

GKT137831是针对NOX1和NOX4酶的一流抑制剂。

靶点信息

NOX1NOX4
110 nM(Ki)140 nM(Ki)

化学数据

目录号A14433
作用机制Inhibitor (抑制剂)
M. Wt394.85
FormulaC21H19ClN4O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1218942-37-0
SynonymsGKT-137831, GKT 137831
SMILESCN1C(=O)C=C2C(=C1C3=CC(=CC=C3)N(C)C)C(=O)N(N2)C4=CC=CC=C4Cl

溶解度

In vitro (25°C)DMSOWarmed: 72 mg/mL (182.34 mM)
WaterInsoluble
EthanolInsoluble
In vivo2% DMSO+2% Tween 80+30% PEG 300+ddH2O8 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM25.33 mL126.63 mL253.26 mL
0.5 mM5.07 mL25.33 mL50.65 mL
1 mM2.53 mL12.66 mL25.33 mL
5 mM0.51 mL2.53 mL5.07 mL

*The above data is based on the productmolecular weight 394.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.