TD-198946 is a thienoindazole analogue, has been found to be active in the studies as a chondrogenic factor. Cell-sheet technology combined with a thienoindazole analogue small compound TD-198946 for cartilage regeneration. A novel disease-modifying osteoarthritis drug candidate targeting Runx1. References: Yano F, Ohba S, Hosaka Y, Saito T, Chung UI. Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis. 2014 Nov;73(11):2062-4. doi: 10.1136/annrheumdis-2014-205672. Epub 2014 Aug 18. PubMed PMID: 25135252.
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CAS:364762-86-7