HMR-1556 is a potent and selective Iks channel blocker (IC50 are 10.5 and 34 nM). HMR-1556 selectively inhibits IKs currents over IKr, IKI, Ito and L-type Ca2+ channel currents. References: So PP, Backx PH, Dorian P. Slow delayed rectifier K+ current block by HMR 1556 increases dispersion of repolarization and promotes Torsades de Pointes in rabbit ventricles. Br J Pharmacol. 2008 Dec;155(8):1185-94. doi: 10.1038/bjp.2008.354. PubMed PMID: 18836478; PubMed Central PMCID: PMC2607203.
纯度:≥98%
CAS:223749-46-0