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H3B-6545
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
H3B-6545图片
CAS NO:2052130-80-8
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
H3B-6545 (H3B 6545; H3B6545) is a novel, potent, orally bioavailable and selective small molecule modulator of wild-type and mutant Estrogen Receptor (ERα), also called estrogen receptor covalent antagonist (SERCA). Preclinical data indicates H3B-6545 inhibits the growth of cell line and patient-derived xenograft models of wild-type and mutant ERα with improved activity over standard-of-care therapies.
理化性质和储存条件

Molecular Formula: C30H29F4N5O2;

Exact Mass: 567.2257
Molecular Weight: 567.5886

Synonym: H3B-6545; H3B 6545; H3B6545;

Chemical Name:(E)-N,N-dimethyl-4-((2-((5-((Z)-4,4,4-trifluoro-1-(3-fluoro-1H-indazol-5-yl)-2-phenylbut-1-en-1-yl)pyridin-2-yl)oxy)ethyl)amino)but-2-enamide

InChi Key:JPFTZIJTXCHJNE-HMOQVRKWSA-N

InChi Code:InChI=1S/C30H29F4N5O2/c1-39(2)27(40)9-6-14-35-15-16-41-26-13-11-22(19-36-26)28(21-10-12-25-23(17-21)29(31)38-37-25)24(18-30(32,33)34)20-7-4-3-5-8-20/h3-13,17,19,35H,14-16,18H2,1-2H3,(H,37,38)/b9-6+,28-24-

SMILES Code:FC1=NNC(C=C2)=C1C=C2/C(C3=CC=C(OCCNC/C=C/C(N(C)C)=O)N=C3)=C(CC(F)(F)F)/C4=CC=CC=C4