GYKI-46903 is a non-competitive antagonist for 5-HT3 receptors. In displacement studies, the pIC50 of GYKI-46903 against [3H]granisetron binding to rat cerebral cortex membranes were 6.91. GYKI-46903, when administered by intravenous infusion, antagonized the decrease in heart rate evoked by serotonin (Bezold-Jarisch reflex) in anaesthetized rats, and the maximal reversal was less than 50%. References: Maksay G, Bíró T, Bugovics G. Allosteric modulation of 5-HT3 serotonin receptors. Eur J Pharmacol. 2005 May 2;514(1):17-24. Epub 2005 Apr 22. PubMed PMID: 15878320.

纯度：≥98%

CAS：142999-59-5